Improvement of memory deficits via acetylcholinesterase inhibitory activity of Nepeta nuda ssp. nuda essential oil in rats
نویسندگان
چکیده
Nepeta L. (Lamiaceae) species are belonging to aromatic and medicinal plants. Many biological activities of have been reported. In this study, memory-enhancing nuda ssp. essential oil was aimed be evaluated in laboratory rats treated with scopolamine. GC-MS/GC-FID system used identify composition. Memory performances the were tested using Y-maze radial-arm maze. Acetylcholinesterase enzyme activity molecular docking analysis also performed study. total, 44 different compounds identified oil. Trans-cis nepetalactone showed most abundant constituent test, improved animals on spontaneous alternation. Besides, maze working reference memory significantly impaired subjected The acetylcholinesterase inhibitory vitro. method, meantime, revealed that some could interact enzyme, theoretically. spatial scopolamine-induced rats. Neuroprotective effects probably related anti-cholinesterase Therefore, as a complementary therapy improve Alzheimer’s diseases.
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ژورنال
عنوان ژورنال: kuwait journal of science
سال: 2021
ISSN: ['2307-4108', '2307-4116']
DOI: https://doi.org/10.48129/kjs.v48i3.9217